Probing membrane asymmetry of ABC polymersomes.


Department of Physical Chemistry, University of Basel, Mattenstrasse 24a, BPR 1096, 4058 Basel, Switzerland. [Email] and Precision Macromolecular Chemistry, Institute Charles Sadron, UPR-22 CNRS, BP 84047, 23 rue du Loess, 67034 Strasbourg Cedex 2, France. [Email]


We report the sensitivity of the membrane asymmetry of ABC (PEO-b-PCL-b-PMOXA) polymersomes towards the end-group modification of a shorter C block. While a non-modified ABC polymer formed polymersomes with the A block outside and the C block inside, a mixture of ABC and ABC-biotin formed polymersomes with the C block outside.