Progression of Parkinson's disease patients' subtypes based on cortical thinning: 4-year follow-up.


Medical Psychology Unit, Department of Medicine. Institute of Neuroscience, University of Barcelona, Barcelona, Catalonia, Spain. Electronic address: [Email]


Three cortical atrophy patterns were previously identified in non-demented Parkinson's disease patients using a data-driven approach based on cortical thickness data: i) parieto-temporal pattern of atrophy with worse cognitive performance (pattern 1), ii) occipital and frontal cortical atrophy with younger disease onset (pattern 2), and iii) non-detectable cortical atrophy (pattern 3). We aimed to investigate the evolution of these three patterns over time.


Cluster analysis,Cortical atrophy,Longitudinal assessment,Magnetic resonance imaging,Parkinson disease,