Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease.


Proteomics Unit, Department of Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: [Email]


Alzheimer's disease (AD) is the most common neurodegenerative disorder. Depositions of amyloid β peptide (Aβ) and tau protein are among the major pathological hallmarks of AD. Aβ and tau burden follows predictable spatial patterns during the progression of AD. Nevertheless, it remains obscure why certain brain regions are more vulnerable than others; to investigate this and dysregulated pathways during AD progression, a mass spectrometry-based proteomics study was performed.


Alzheimer's disease,Braak/Braak staging,Brain region vulnerability,Medial temporal lobe,Neocortex,Proteomics,