Pyrimidines and Cyclic Trinucleotides Join the Second Messenger Symphony.


Department of Microbiology & Molecular Genetics, Michigan State University, East Lansing, MI, USA. Electronic address: [Email]


In recent work, Whiteley et al. (2019) define a family of bacterial nucleotidyltransferases (CD-NTases) capable of synthesizing pyrimidine containing cyclic dinucleotides and cyclic trinucleotides. CD-NTases are broadly distributed across bacterial phyla, suggesting that they play important roles in bacterial physiology and modulation of the metazoan host innate immune system.