Quinoline-derivative coordination compounds as potential applications to antibacterial and antineoplasic drugs.

Affiliation

Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Laboratório de Química de Calixarenos, Espectroscopia Molecular e Catálise, Universidade Federal de São Paulo, Rua Prof. Arthur Riedel, 275, CEP 09972-270 Diadema, SP, Brazil. Electronic address: [Email]

Abstract

Quinoline-derivative coordination compounds were synthesized with Zn(II), Al(III), Cu(II), Ru(II) producing 1-4 compounds using 5-nitro-8-hydroxyquinoline and 5-8 compounds using 5-chloro-8-hydroxyquinoline. These coordination compounds were characterized by elemental analysis and 1H NMR, IR, UV-Vis and fluorescence spectroscopies, representing the coherent data matched all compounds. Myelotoxicity data, as well as the biochemical data, depicted the compounds have low cytotoxicity towards the blood cells. All coordination compounds displayed slight antimicrobial activity against E. coli, S. aureus, P. aeruginosa and E. faecalis; [RuCl(NO)(5-chloro-8-oxyquinoline)2] compound (8) represent the best result to inhibitions of Gram-positive and Gram-negative bacteria. Antineoplasic action depicted the [Ru(NO)(5-nitro-8-oxyquinoline)2Cl] compound (4) as a potential chemotherapeutic agent against MCF-7 (a breast cancer cell line), compared to cisplatin (Platistine® CS) and cyclophosphamide (Genuxal®) drugs.

Keywords

Antimicrobial,Antineoplasic action,Cell viability,Cytotoxicity,Myelotoxic,Quinoline compounds,