Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations.

Affiliation

INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; ELI-Beamline Project, Inst. Physics, ASCR, PALS Center, Prague, Czech Republic. Electronic address: [Email]

Abstract

OBJECTIVE : The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams.
METHODS : The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data.
CONCLUSIONS : The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.

Keywords

Geant4,Monte Carlo,Proton,RBE,Radiobiological model,Radiotherapy,Survival fraction,

OUR Recent Articles