Rapid detection of insulin by immune-enrichment with silicon-nanoparticle-assisted MALDI-TOF MS.


Department of Clinical Laboratory Medicine, TaiZhou Central Hospital (Taizhou University Hospital), No.999 Donghai Road, Jiaojiang District, Taizhou, Zhejiang, 318000, China. Electronic address: [Email]


Insulin is central to regulating fat and carbohydrate metabolism in the body. However, it is difficult to detect insulin using mass spectrometry (MS). The integration of nanotechnology with mass spectrometry for selective and sensitive detection is an important research area. Our aim was to establish a method to detect insulin using silicon nanoparticle-assisted high-throughput MS.


Immune-enrichment,Insulin,MALDI-TOF MS,Silicon nanoparticles,

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