Recommendations for selection of additives for stabilization of [18F]FDG.

Affiliation

Medical Imaging Department Division of Nuclear Medicine and Translational Imaging, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary. Electronic address: [Email]

Abstract

In this work, two relevant recommendations were established for selection of stabilizers for suppression of radiolysis of [18F]FDG. First, the stabilizing effect could be enhanced using selective scavengers of hydroxyl radicals (OH·). Additionally, the initial radiochemical purity could be retained due to compounds with rate constants of their reactions with OH· (kOH) higher than 109 M-1 s-1. According to these recommendations number of additives among carbohydrates, amino acids, B vitamins and organic salts were successfully applied for stabilization of [18F]FDG.

Keywords

Radiochemical stability,Radiolysis,Scavengers,[(18)F]FDG,

OUR Recent Articles