Repetitive transcranial magnetic stimulation (rTMS) modulates time-varying electroencephalography (EEG) network in primary insomnia patients: a TMS-EEG study.


Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neuromodulation, Beijing, China. Electronic address: [Email]


Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method, and its application in the treatment of primary insomnia (PI) is poorly researched. PI is considered to be a functional disorder with abnormal brain network connections. TMS combined electroencephalography (EEG) is a valuable method for directly probing excitability and dynamic connectivity of different regions in the brain. We aimed to investigate the therapeutic efficacy of rTMS and its impact on brain network connections in PI patients.


Adaptive directed transfer function,Primary insomnia,Right posterior parietal cortex,Time-varying EEG network,rTMS,