Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons.

Affiliation

Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, New York; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York. Electronic address: [Email]

Abstract

Early life adversity (ELA) increases major depressive disorder (MDD) and suicide risk and potentially affects dentate gyrus (DG) plasticity. We reported smaller DG and fewer granular neurons (GNs) in MDD. ELA effects on DG plasticity in suicide decedents with MDD (MDDSui) and resilient subjects (ELA history without MDD or suicide) are unknown.

Keywords

Granule cell,Major depression,Neural progenitors,Postmortem,Stress,Suicide,