SLIMEr: probing flexibility of lipid metabolism in yeast with an improved constraint-based modeling framework.


Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. [Email]


A recurrent problem in genome-scale metabolic models (GEMs) is to correctly represent lipids as biomass requirements, due to the numerous of possible combinations of individual lipid species and the corresponding lack of fully detailed data. In this study we present SLIMEr, a formalism for correctly representing lipid requirements in GEMs using commonly available experimental data.


Flux balance analysis,Genome-scale metabolic modeling,Lipidomics,Saccharomyces cerevisiae,