Scalable, efficient and rapid chemical synthesis of l-Fructose with high purity.


Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: [Email]


An improved process for chemical synthesis of l-fructose with high purity in large scale from readily available l-sorbose is described. In general, this synthetic scheme is characterized by inexpensive and easily available starting materials, simple and safe experimental procedures, short time period, low environmental impact, and great potential for scaling up. The scale-up experiment (100 g) was carried out to provide 42.7 g of l-fructose with high HPLC purity of 99.65% in total yield of 50.2%. Consequently, the described improvements would be helpful for those who may wish to use l-fructose and promoting the further evaluation of applications of l-fructose.


Good yield,High purity,L-fructose,Scalable synthesis,Short time period,

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