Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study.

Affiliation

Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Stanley Center for Psychiatric Research, The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts. Electronic address: [Email]

Abstract

Exposure to early-life adversity is known to predict DNA methylation (DNAm) patterns that may be related to psychiatric risk. However, few studies have investigated whether adversity has time-dependent effects based on the age at exposure.

Keywords

Childhood adversity,Children,DNA methylation,Epigenetics,Longitudinal,Sensitive periods,