Sequencing of therapy following first-line afatinib in patients with EGFR mutation-positive non-small cell lung cancer.


Aichi Cancer Center, 1-1 Kanokoden, Chikusa Ward, Nagoya, Aichi Prefecture, 464-8681, Japan. Electronic address: [Email]


With the availability of several epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), sequential therapy could potentially render EGFR mutation-positive non-small cell lung cancer a chronic disease in some patients. In this retrospective analysis of EGFR mutation-positive (Del19/L858R) patients receiving first-line afatinib in LUX-Lung 3, 6, and 7, we assessed uptake of, and outcomes following, subsequent therapies including the third-generation EGFR TKI, osimertinib.


Afatinib,Non-small cell lung cancer,Osimertinib,

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