Men's Health Boston, Chestnut Hill, MA, USA; Harvard University, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: [Email]
The testosterone (T) status of a man is influenced by serum concentrations of sex hormone-binding globulin (SHBG). Specifically, tight binding of T to SHBG is believed to render the SHBG-bound T fraction biologically unavailable, meaning that interpretation of T levels in the clinical setting depends in part on knowledge of SHBG concentrations. Although SHBG levels have been reported in population studies, there is scant information for men presenting with clinical symptoms.
