Serum soluble ST2 as a marker of renal scar in pediatric upper urinary tract infection.


Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Japan. Electronic address: [Email]


Upper urinary tract infection is the most common serious bacterial infection in childhood. Patients with upper urinary tract infection have a risk for renal scarring with subsequent complications including hypertension, proteinuria, and progressive renal failure. However, the predictive biomarkers of renal scarring in children with upper urinary tract infection are still unknown. In this study, we evaluated whether soluble ST2 levels can be biomarkers of subsequent renal scarring in patients with upper urinary tract infection.


Acute focal bacterial nephritis,Acute pyelonephritis,Cytokine,Renal scarring,Soluble ST2,Upper urinary tract infection,