Severity-dependent and -independent brain regions of major depressive disorder: A long-term longitudinal near-infrared spectroscopy study.


Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: [Email]


Long-term longitudinal studies are necessary to establish neuroimaging indicators which contribute to the detection of severity changes over time in patients with major depressive disorder (MDD).


Abbreviations: MDD, major depressive disorder,Biological marker,CBF, cerebral blood flow,CH, channel,DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition,FDR, false-discovery rate,GAF, Global Assessment of Functioning,HAMD, Hamilton Rating Scale for Depression,ICCs, intra-class correlation coefficients,IFG, inferior frontal gyrus,IQ, Intelligence Quotient,JART, Japanese Adult Reading Test,Long-term longitudinal study,MFG, middle frontal gyrus,MRI, magnetic resonance imaging,Major depressive disorder (MDD),Mood disorder,NIRS, near-infrared spectroscopy,Near-infrared spectroscopy (NIRS),PET, positron emission tomography,PFC, prefrontal cortex,SCID, Structured Clinical Interview for DSM-IV,VFT, verbal fluency test,