Short-term dynamics of input and output of CA1 network greatly differ between the dorsal and ventral rat hippocampus.

Affiliation

Laboratory of Neurophysiology, Department of Medicine, University of Patras, 26504, Rion, Greece. [Email]

Abstract

The functional heterogeneity of the hippocampus along its longitudinal axis at the level of behavior is an established concept; however, the neurobiological mechanisms are still unknown. Diversifications in the functioning of intrinsic hippocampal circuitry including short-term dynamics of synaptic inputs and neuronal output, that are important determinants of information processing in the brain, may profoundly contribute to functional specializations along the hippocampus. The objectives of the present study were the examination of the role of the GABAA receptor-mediated inhibition, the μ-opioid receptors and the effect of stimulation intensity on the dynamics of both synaptic input and neuronal output of CA1 region in the dorsal and ventral hippocampus. We used recordings of field potentials from adult rat hippocampal slices evoked by brief repetitive activation of Schaffer collaterals.

Keywords

Dorsoventral,Excitability,Hippocampus,In vitro,Inhibition,Mu opioid receptor,Rat,Septotemporal,Short-term dynamics,Short-term plasticity,

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