Sleep spindles and K-complex activities are decreased in spinocerebellar ataxia type 2: relationship to memory and motor performances.

Affiliation

Centre for the Research and Rehabilitation of Hereditary Ataxias, Holguín, Cuba; Cuban Academy of Sciences, Havana, Cuba; Faculty of Sport and Physical Culture, University of Holguín, Holguín, Cuba; Medical University of Holguín, Holguín, Cuba. Electronic address: [Email]

Abstract

Sleep spindles and K-complexes are electroencephalographic hallmarks of non-rapid eye movement (non-REM) sleep that provide valuable information into brain functioning, plasticity and sleep functions in normal and pathological conditions. However, they have not been systematically investigated in spinocerebellar ataxias (SCA). To close this gap, the current study was carried out to quantify sleep spindles and K-complexes in SCA2 and to assess their relationship with clinical and molecular measures, as well as with memory and attention/executive functioning.

Keywords

K-complexes,NREM sleep microstructure,Sleep spindles,Spinocerebellar ataxia type 2,

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