Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Affiliation

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom. Electronic address: [Email]

Abstract

The β-lactam antibiotics represent the most successful drug class for treatment of bacterial infections. Resistance to them, importantly via production of β-lactamases, which collectively are able to hydrolyse all classes of β-lactams, threatens their continued widespread use. Bicyclic boronates show potential as broad spectrum inhibitors of the mechanistically distinct serine- (SBL) and metallo- (MBL) β-lactamase families.

Keywords

Antimicrobial clinical coverage,Cyclic boronate inhibitors,Metallo and serine β-lactamase inhibition,Transition state analogue,β-lactam antibiotic resistance,β-lactamase induction,

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