In this paper, the mechanism of enhanced membrane separation by ultrasound is analyzed. The main factors affecting the separation of enhanced membrane by ultrasonic technology is studied, the application and research progress of ultrasonic technology in membrane separation are studied. The conclusion are (a) cavitation caused by ultrasonic radiation is the main factor that increases the permeation flux of dextran solution (b) higher intensity of sound is helpful to the cleaning of the film; (c) ultrasound enhancement is related to temperature and operating pressure; (d) the film assembly shell material also affect the ultrasonic effect. In addition, the influence of ultrasonic wave on membrane structure is also discussed. Result indicates that the membrane separation process under the action of ultrasound does improve its permeability, but sometimes ultrasound can also cause damage to the membrane. Application of ultrasonic techniques for enhancing the separation process of membrane is also reviewed.