Substantia nigra locations of iron-content, free-water and mean diffusivity abnormalities in moderate stage Parkinson's disease.


ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France. Electronic address: [Email]


Prior work demonstrated that free water in the posterior substantia nigra (SN) was elevated in Parkinson's disease (PD) compared to healthy controls (HC) across single- and multi-site cohorts, and increased over 1 year in Parkinson's disease but not in relation with the iron deposition in SN with the relaxometry T2*.


Free-water,Iron,MRI,Parkinson's disease,Substantia Nigra,