Substantia nigra locations of iron-content, free-water and mean diffusivity abnormalities in moderate stage Parkinson's disease.

Affiliation

ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, France. Electronic address: [Email]

Abstract

Prior work demonstrated that free water in the posterior substantia nigra (SN) was elevated in Parkinson's disease (PD) compared to healthy controls (HC) across single- and multi-site cohorts, and increased over 1 year in Parkinson's disease but not in relation with the iron deposition in SN with the relaxometry T2*.

Keywords

Free-water,Iron,MRI,Parkinson's disease,Substantia Nigra,

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