Oral human papilloma (HPV) virus is very common in patients. Deep location of lesions can lead to poor therapeutic effects. We are reporting a case of 52-year-old male who was diagnosed of oral papilloma on the left side of the palatoglossal arch. He was treated with local injection of 5-aminolevulinic acid-mediated photodynamic therapy for 2 sessions. There was no obvious recurrence at 6 months of follow-up. This case suggests that sodium chloride injection diluted ALA photosensitizer and injection at lesion basement can achieve good therapeutic results.
