Synbiotic-driven improvement of metabolic disturbances is associated with changes in the gut microbiome in diet-induced obese mice.


School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. Electronic address: [Email]


The gut microbiota is an important influencing factor of metabolic health. Although dietary interventions with probiotics, prebiotics, and synbiotics can be effective means to regulate obesity and associated comorbidities, the underlying shifts in gut microbial communities, especially at the functional level, have not been characterized in great details. In this study, we sought to investigate the effects of synbiotics on the regulation of gut microbiota and the alleviation of high-fat diet (HFD)-induced metabolic disorders in mice.


Dietary intervention,Gut microbiota,High-fat diet,Obesity,Synbiotics,

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