T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation.

Affiliation

Medical Research Council (MRC) Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom. Electronic address: [Email]

Abstract

IL-23 is the key cytokine for generation of pathogenic IL-17-producing helper T (TH17) cells, which contribute critically to autoimmune diseases. However, how IL-23 generates pathogenic TH17 cells remains to be elucidated.

Keywords

IL-23 receptor,Psoriasis,cAMP-responsive element binding protein 1,nuclear factor κ light chain enhancer of activated B cells,pathogenic T(H)17 cells,prostaglandin E receptor EP2,prostaglandin E receptor EP4,prostaglandin E(2),signal transducer and activator of transcription 3,