Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation.

Affiliation

Institute of Physiological Chemistry, University Halle-Wittenberg, Medical Faculty, Hollystrasse 1, 06114, Halle (Saale), Germany. [Email]

Abstract

Overexpression of AXL receptor tyrosine kinase (AXL) in various human cancers correlates with reduced patients overall survival and resistance to first line therapies. Therefore, several AXL tyrosine kinase inhibitors (TKIs) are currently under clinical evaluation.

Keywords

3D spheroid,AXL,Degradation,RTK,TKI,Ubiquitin,

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