Gupta S(1), Rangari KV(1), Mehrotra A(2), Pal L(3), Jaisawal AK(1), Kumar R(1). Author information:
(1)Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical
Sciences, Lucknow, Uttar Pradesh, 226014, India.
(2)Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical
Sciences, Lucknow, Uttar Pradesh, 226014, India. [Email]
(3)Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical
Sciences, Lucknow, Uttar Pradesh, 226014, India.
BACKGROUND: Angiocentric glioma (AG) is a relatively uncommon clinico-pathological entity that presents in childhood. Angiocentric glioma displays various histopathological features which resemble cortical ependymoma, astroblastoma, and pilomyxoid astrocytoma and schwannoma. The astrocytes in angiocentric glioma appear peculiarly elongated, bipolar in shape, and characteristically arranged around blood vessels. They resemble radial glia and tanycytes morphologically. Unlike ependymomas, AG is a diffusely infiltrating lesion and perivascular processes are often much thicker than those in classic ependymomas.
CASE PRESENTATION: AG usually present clinically as seizures, often as medically intractable epilepsy. In the indexed case, apart from unusual presentation with features of raised intra-cranial tension, an unusual histological picture of a more cellular oligodendroglioma like component was also seen.
CONCLUSION: The appropriate diagnosis is critical as AG is usually slowly growing and treatable by surgical excision alone.
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