The Nuclear Lamina as an Organizer of Chromosome Architecture.

Affiliation

Department of Molecular Genetics of Cell, Institute of Molecular Genetics, Russian Academy of Sciences, 123182 Moscow, Russia. [Email]

Abstract

The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its disruption affects gene expression more severely. Normally, the NL serves as a backbone for multiple chromatin anchoring sites, thus shaping the spatial organization of chromosomes in the interphase nucleus. However, upon cell senescence, aging, or in some types of terminally differentiated cells and lamin-associated diseases, the loss of NL-chromatin tethering causes drastic alterations in chromosome architecture. Here, we provide an overview of the recent advances in the field of NL-chromatin interactions, focusing on their impact on chromatin positioning, compaction, repression, and spatial organization.

Keywords

H3K9me2/3,HP1,LAD,TAD,heterochromatin,lamin,nuclear envelope,nuclear lamina,nuclear periphery,

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