The SIZ of Pain.


Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. Electronic address: [Email]


The site of action potential initiation in sensory neurons remains poorly understood. In this issue of Neuron, Goldstein et al. (2019) identified the location of the sodium-dependent spike initiation zone (Nav-SIZ) in nociceptive neurons, showing its plasticity under inflammatory conditions.