The TERT locus genotypes of rs2736100-CC/CA and rs2736098-AA predict shorter survival in renal cell carcinoma.


Department of Medicine and Center for Molecular Medicine (CMM), Karolinska Institutet and Karolinska University Hospital Solna, SE-171 76 Stockholm, Sweden. Electronic address: [Email]


The single nucleotide polymorphisms (SNPs) at the TERT rs2736100 and rs2736098 are associated with multicancer susceptibility, however, published findings regarding renal cell carcinoma (RCC) risk are conflicting. In addition, the potential of these SNPs to predict outcomes in RCC remains unclear. The present study is designed to address these questions.


Abbreviations: CI, confidence interval,HC, healthy control,HR, hazard ratio,OR, odds ratio,OS, overall survival,PFS, progression-free survival,Prognostic factors,RCC, renal cell carcinoma,Renal cell carcinoma,SNP, single nucleotide polymorphism,SNPs,TERT,TERT, telomerase reverse transcriptase,Telomerase,

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