The biochemical and molecular mechanisms involved in the role of tumor micro-environment stress in development of drug resistance.


Department of Pathology and Bosch Institute, Medical Foundation Building (K25), University of Sydney, New South Wales 2006, Australia. Electronic address: [Email]


Multi-drug resistance (MDR) is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Moreover, the tumor micro-environment is essential to the formation of drug resistant cancers. Recent evidence indicates that the tumor micro-environment is a critical regulator of cancer progression, distant metastasis and acquired resistance of tumors to various therapies. Despite significant advances in chemotherapy and radiotherapy, the development of therapeutic resistance leads to reduced drug efficacy.


Apoptosis,Autophagy,Hypoxia,Metabolism,Multi-drug resistance,Tumor micro-environment,