The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.

Affiliation

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: [Email]

Abstract

Administration of glucagon (GCG) or GCG-containing co-agonists reduces body weight and increases energy expenditure. These actions appear to be transduced by multiple direct and indirect GCG receptor (GCGR)-dependent mechanisms. Although the canonical GCGR is expressed in brown adipose tissue (BAT) the importance of BAT GCGR activity for the physiological control of body weight, or the response to GCG agonism, has not been defined.

Keywords

Adiposity,Energy expenditure,Glucagon,Lipolysis,Thermogenesis,brown adipose tissue,

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