The disordered charged biased proteins in the human diseasome.

Affiliation

Laboratory of Plant Protection and Improvement, Center of Biotechnology of Sfax, University of Sfax, Route Sidi Mansour, PO Box 1177, 3018, Sfax, Tunisia. [Email]

Abstract

Intrinsically disordered proteins (IDPs) are often involved in diseases and have been shown to be promising targets for drug development. Here, we focus on the human disordered charged biased proteins (HDCBPs). We have investigated the association of the HDCBPs with diseases by integrating various sources that cover public sources of gene-disease associations and intensive literature mining. The results indicate that 95% of HDCBPs are associated with multiple diseases, including mainly various cancers, nervous, endocrine, immune, hematological, and respiratory systems diseases. Our data show that the HDCBP-disease network constructed by integrating different levels of data together may improve our understanding of these complex diseases. Moreover, we present the top-ranked proteins that might be potential markers for diagnostic and drug targets.

Keywords

Charged biased proteins,Disease association,Drugs,Therapeutic target,