The impact of variant classification on the clinical management of hereditary cancer syndromes.


Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. [Email]


The reclassification of genetic variants poses a significant challenge for laboratories and clinicians. Variant review has resulted in the reclassification of variants of unknown significance as well as the reclassification of previously established pathogenic and likely pathogenic variants. These reclassifications have the potential to alter the clinical management of patients with hereditary cancer syndromes.


Clinical impact,Hereditary cancer clinic,Hereditary cancer syndrome,Variant reclassification,,