The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis.

Affiliation

Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. [Email]

Abstract

The ubiquitin proteasome system (UPS) regulates the expression levels of cellular proteins by ubiquitination of protein substrates followed by their degradation via the proteasome. As a highly conserved cellular degradation mechanism, the UPS affects a variety of biological processes and participates in viral propagation.

Keywords

Hepatitis B virus,Pathogenesis,Proteasome,Replication,Ubiquitin,

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