The presence and variant allele fraction of EGFR mutations in ctDNA and development of resistance.


Princess Margaret Cancer Centre/University Health Network, Toronto, Canada. Electronic address: [Email]


Peripheral blood sampling for detection of EGFR T790M in cell-free circulating tumour (ct) DNA in TKI-resistant EGFR mutant (EGFRm) lung cancer is now standard. The value of more comprehensive sequencing is unknown.


EGFR mutation,Non-small cell lung cancer,Resistance,Variant allelic fraction,

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