The role of chamaejasmine in cellular apoptosis and autophagy in MG-63 cells.

Affiliation

Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China [Email]

Abstract

Osteosarcoma (OS) is the most common malignant neoplasm in children and adolescents with a very high propensity for local invasion and poor response to current therapy. Anti-cancer effect of chamaejasmine is newly discovered from Stellera chamaejasmine L. Our study focuses on investigating the effect of chamaejasmine on the cellular apoptosis, proliferation, autophagy, and the underlying mechanisms in MG-63.

Keywords

AMPK/mTOR,apoptosis,autophagy,chamaejasmine,osteosarcoma,