Thermodynamic Activity-Based Solvent Design for Bioreactions.

Affiliation

Laboratory of Thermodynamics, Department of Biochemical and Chemical Engineering, Technische Universität (TU) Dortmund, Emil-Figge-Strasse 70, 44227 Dortmund, Germany. Electronic address: [Email]

Abstract

To improve the kinetics of enzyme-catalyzed reactions, cosolvents are commonly added to reaction mixtures. The search for a good cosolvent is still empirical and experimentally based. We discuss a thermodynamic activity-based approach that improves biocatalytic processes by predicting cosolvent influences on Michaelis constants, ultimately reducing time and cost.

Keywords

Michaelis constant,activity coefficients,biocatalysis,cosolvent,ePC-SAFT,predictions,

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