Thyroid Nodule DNA Methylation Signatures: An Important Diagnostic Annotation.


Department of Surgery, McGill University Health Center, Montreal, Quebec, Canada. [Email]


Molecular profiling in thyroid cancer has made significant progress in part due to advances in somatic mutation profiling. Yet, differentiating benign from malignant thyroid nodules remains elusive. A unique set of DNA methylation signatures has the potential of improving thyroid cancer molecular diagnostics based on the DNA methylome.See related article by Yim et al., p. 544.