UHPLC-QTOF/MS-based metabolomics investigation for the protective mechanism of Danshen in Alzheimer's disease cell model induced by Aβ1-42.

Affiliation

School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai, 200433, China. [Email]

Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disorder with neither definitive pathogenesis nor effective therapy so far. Danshen, the dried root and rhizome of Salvia miltiorrhiza Bunge, is used extensively in Alzheimer's disease treatment to ameliorate the symptoms, but the underlying mechanism remains to be clarified.

Keywords

Alzheimer’s disease,Cell metabolomics,Danshen,Human brain microvascular endothelial cell,Metabolic profiling,Ultra high performance liquid chromatography–quadrupole time of flight mass spectrometry,