Uncovering a New Step in Sliding Nucleosomes.

Affiliation

TC Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA. Electronic address: [Email]

Abstract

Chromatin remodelers are ATP-driven motors that pump double-stranded DNA around the histone core of the nucleosome. Recent work by Chen and coworkers (Li et al., Nature, 2019 and Yan et al., Nat. Struct. Mol. Biol., 2019) has revealed an unexpected intermediate where initial translocation involves only one of the two DNA strands.

Keywords

DNA translocation,chromatin remodelers,histone core,nucleosome sliding,twist defect,

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