The interpretation of the calculated result of the revised NIOSH Lifting Equation (RNLE) has been problematic because the relationship of the calculated result to back injury risk has not always been either well understood nor consistently interpreted. During the revision of the ISO standard 11228-1 (Manual lifting, lowering and carrying), an extensive literature review was conducted on validation studies of the RNLE. A systematic review of exposure-risk associations between the LI metrics and various low-back health outcomes from peer-reviewed epidemiological studies was conducted. Risk interpretations for different levels of calculated result of the RNLE are added to the ISO standard. Rationale for the risk interpretations is presented in this paper.