Using Variation in Heritability Estimates as a Test of G × E in Behavioral Research: A Brief Research Note.

Affiliation

Department of Biology, Saint Louis University, 3507 Laclede Ave, Saint Louis, MO, 63103, USA. [Email]

Abstract

Better characterization of the sources of phenotypic variation in human behavioural traits-stemming from genetic and environmental influences-will allow for more informed decisions about how to approach a range of challenges arising from variation, ranging from societal issues to the treatment of diseases. In particular, understanding how the environment moderates genetic influence on phenotypes (i.e., genotype-environment interactions, or G × E) is a central component of the behavioral sciences. Yet, understanding of this phenomenon is lagging somewhat, due in part to the difficulties of detecting G × E. We discuss the logic behind one of the primary ways to detect G × E: comparing heritability estimates across environments. Then, we highlight some pitfalls, with an emphasis on how very strong G × E can sometimes be undetectable using this method when high heritability is present in multiple environments. We conclude by forwarding some initial, yet tentative, suggestions for how best to address to the problem.

Keywords

Behavioral genetics,Gene by environment interaction,Heritability,Quantitative genetics,

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