Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer's disease by applying methodology from gene co-expression analysis.

Affiliation

Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan. Electronic address: [Email]

Abstract

We aimed to identify modularized structural atrophy of brain regions with a high degree of connectivity and its longitudinal changes associated with the progression of Alzheimer's disease (AD) using weighted gene co-expression network analysis (WGCNA), which is an unsupervised hierarchical clustering method originally used in genetic analysis.

Keywords

Alzheimer's disease module,Brain atrophy,Connectivity,Hierarchical clustering,Mild cognitive impairment,

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