Z-505, an Oral Ghrelin Receptor Agonist, Attenuates Anorexia After Total Gastrectomy in Rats.

Affiliation

Central Research Laboratories, Zeria Pharmaceutical Co, Ltd, Kumagaya-shi, Saitama, Japan; Agrobioscience, Graduate School of Agricultural Science, Kobe University, Nada-ku, Hyogo, Japan. Electronic address: [Email]

Abstract

Anorexia is a serious problem in patients with gastric cancer who have undergone gastrectomy. Ghrelin, an orexigenic hormone primarily secreted from the stomach, has been proposed to prevent anorexia. Significant reduction in plasma ghrelin levels after gastrectomy may contribute to lack of appetite and weight loss. In this study, we investigated the effects of Z-505, a ghrelin receptor agonist, on anorexia after total gastrectomy (TG) in a rat model.

Keywords

Anorexia,Ghrelin,Hypothalamic arcuate nucleus,Total gastrectomy,Z-505,

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