cAMPing out with the keepers of the gate: Adenylyl cyclases get cozy with Orai.


VA Boston Healthcare System and the Dept. of Surgery, Brigham & Women's Hospital and Harvard Medical School, 1400 VFW PKW, West Roxbury, MA 02132, USA. Electronic address: [Email]


Calcium and cyclic AMP form the cornerstones of two ancient signaling systems represented in nearly every kingdom of life. Not surprisingly, these old and ubiquitous messenger molecules have co-evolved multiple means to regulate one another. Zhang et al. describe a new twist on this theme related to the intimate union between the calcium-activated adenylyl cyclase, AC8, and the store-operated Ca2+ channel, Orai1.


Adenylyl cyclase,Calcium channels,Cyclic AMP,Electrophysiology,Patch clamp,

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