miR-132-3p is a positive regulator of alpha-cell mass and is downregulated in obese hyperglycemic mice.

Affiliation

Laboratory of Molecular Diabetes, Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital/Diabetes Center/University of Geneva Medical School, Geneva, Switzerland. Electronic address: [Email]

Abstract

Diabetes is a complex disease implicating several organs and cell types. Within the islets, dysregulation occurs in both alpha- and beta-cells, leading to defects of insulin secretion and increased glucagon secretion. Dysregulation of alpha-cells is associated with transcriptome changes. We hypothesized that microRNAs (miRNAs) which are negative regulators of mRNA stability and translation could be involved in alpha-cell alterations or adaptations during type 2 diabetes.

Keywords

Alpha-cell,Apoptosis,Glucagon,Proliferation,Type 2 diabetes,miR-132-3p,