p53 and β-Catenin Expression Predict Poorer Prognosis in Patients With Anaplastic Large-Cell Lymphoma.


Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS. Electronic address: [Email]


The Wnt/β-catenin signaling pathway is a major target of p53. β-Catenin/p53 coexpression predicts poorer survival in carcinoma patients. Conversely, CD99 inhibits tumor metastasis through the Wnt/β-catenin pathway. We therefore assessed p53, β-catenin, and CD99 by immunohistochemistry.


ALCL,ALK,Survival,Wnt signaling,β-Catenin,