Expression of Oct4 and RhoA in gastric cancer and their correlation with clinicopathological characteristics

Authors: Meiling Hao, Haiwang Liu, Xing Zhao, Chunhui Li

Author's unit: Pathology Department of the Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei.

First author: Hao Meiling (1989 -), female, Chengde City, Hebei Province, attending physician, mainly engaged in tumor diagnosis; E-mail: 15632495450@163.com; Tel.: 15632495450; Department of Pathology, Affiliated Hospital of Chengde Medical College, No. 36, Nanyingzi Street, Shuangqiao District, Chengde City, Hebei Province.

Corresponding author: Li Chunhui (1965 -), male, chief physician of Chengde City, Hebei Province, mainly engaged in tumor diagnosis; E-mail: chli612@126.com; Tel.: 15633142839; Department of Pathology, Affiliated Hospital of Chengde Medical College, No. 36, Nanyingzi Street, Shuangqiao District, Chengde City, Hebei Province.

Article Under Review

Objective

To investigate the correlation between the expression of Oct4 and RhoA in gastric cancer and its clinical value.

The expression of Oct4 and RhoA in 30 gastric cancer specimens and normal gastric mucosa was detected by immunohistochemistry, and the correlation between them and clinicopathological features was analyzed.

The immunohistochemical results showed that the expression of Oct4 and RhoA was related to tumor grade, lymph node metastasis and distant metastasis, and the difference was statistically significant (P<0.05). There was no significant difference between the two groups (P>0.05). Oct4 was positively correlated with RhoA.

Oct4 and RhoA are correlated in gastric cancer, and Oct4 and RhoA play an important role in the occurrence and development of gastric cancer.

Oct4, RhoA, Immunohistochemistry, gastric cancer