Prof Odeh S O
Dr Jimmy E O, Lipton tea and coffee complicate pathogenesis of its induced gastric ulcer with fluctuations in amylase and protein levels(2017)SDRP Journal of Cellular and Molecular Physiology 2(1)
Gastric and plasma alpha amylase and proteins concentrations were evaluated in male and female albino rats fed with Lipton tea and coffee induced gastric ulcer. A total of ninety-six male and female albino rats were studied for 28 days. There was no significant difference (p>0.5) in gastric alpha amylase concentrations between the two beverages and the male and female rats. Also there was no significant difference in plasma alpha amylase between Lipton tea and coffee, (P>0.05) and between sexes, (p>0.05). However, the plasma alpha amylase values were very low as compared to control rats without gastric ulcer. There was significant difference in plasma protein concentrations between rats fed with coffee and Lipton tea, (p<0.05) as more proteins concentrations were recorded in coffee feeding than in Lipton tea. Also there was significant difference in plasma protein concentrations in the weekly studies of 7, 14, 21, 28 days (p>0.05). And no significant differences (p>0.05) between the sexes and rats fed with caffeinated and decaffeinated coffee. Cumulatively, both gastric and plasma proteins showed no significant difference, (p>0.5) in their concentrations in Lipton tea and coffee. But there was significant difference (p<0.05) in gastric protein between caffeinated and decaffeinated coffee. Significant differences, (p<0.05) also existed in gastric protein concentrations between 7, 14, 21 and 28 days. Both Lipton tea and coffee induced gastric ulcer, reduced amylase and increased protein concentrations and such may be associated with panccreatitis, kidney disease, multiple myeloma, bone marrow disorder, chronic inflammatory conditions and amyloidosis.
Key words: Amylase, proteins, Lipton tea, coffee, gastric ulcer.
Beckman Unicel (2011 ? 2012) Total protein in Refrigerated serum. Daksinamutthy R. Charles, L. Jiahon, J.K. and Thala Puranam K.S.J (2009) Trichlroacetic acid ?induced protein precipitation involves the reversible association of a stable partially structured intermediate. Protein Science 18(5) 980 ? 993.
Emara, S.S., and Alzaylai, A.A. (2013). Renal failure in burns patient: A. Review. Annals of Burns fire disaster 26 (1) 12 ? 15.
Frank, A.R. (1960) Serum amylase in peptic gastro-duodenal perforation - A study to determine the significance of abnormality high levels. Calif.med 93 (1) 6-10.
Guyton A.C., Hall J.E. (2011). In textbook of medical physiology 12th ed.
Jimmy, E.O. Odeh S.O., Adelaiye, A.B. (2013) Hypergastrinaemia and raised HCL in tea drinking associated gastric ulcer. Journal of physiobiochemical and metabolism 2(2) 2 ? 4.
Kei N. (2016) Low serum amylase and obesity, Diabetes and metabolic syndrome: A novel interpretation. World J. Diabetes 7(6) 112 ? 121. PMid:27022442 PMCid:PMC4807301View Article PubMed/NCBI
Kenneth, T. Jon A.S. Jan T.K., Tom, G. and Kjetil S. (2013) Epidemiology of perforated peptic ulcer: Age and gender adjusted analysis of incidence and mortality. World journal of gastroenterology. 19(3) 347 ? 354. PMid:23372356 PMCid:PMC3554818View Article PubMed/NCBI
Kikawa A. Iwakiri R., Ortani H. Fwise, T. Sakata, Amemori, S. Tsunada, H. saka, T. Koyamla, T. (2005) prevention of re-hemorrhage of bleeding peptic ulcers, effects of H. Pylon eradication an d acid suppression . Alimentary pharmacology & Therapeutics 21:29.
Klein J.G. Poppe, W., and Rauscher E. (1996) Evaluation of a new Alpha Amylase Asay J. Chromatog B. Biomed Appl. 684, 217.
Korman, M.G. Soreny, L. Hansky, J. (1971) Effect of food or serum gastrin evaluated by immunoassay GUT 12: 619 ? 624. PMid:18668828 PMCid:PMC1411765View Article PubMed/NCBI
Kruse, J.D., Jares, C.K. (1989) Evaluation of a new Alpha Amylase, As say using, 4 ? 6 Ethylidene. (G7) ? 1 ? 4 nitrophenyl ? (gi) x ?D- maltoheptasoide as substrate. J. Clin Chem. Clin. Biochem 27, 109 ? 113.
Lenninger, N.D., Cox, I.M. (2000) In principles of Biochemistry, 3rd ed. Texas.
Lin, HJ. & Perng, C.L. (1993) Endoscopic injection for arrest of peptic ulcer haemorrhage. Final results of a prospective randomized comparative Trial Gastrointestinal Endoscopy 39, 15-9. 70003-6View Article
Luca, F. Franca, P. laura, B. (Giogio, C. (2005) pancreatic hyperenzymemia; clinical significance and diagnostic approach journal of pancreas 6 (6) 536 ? 551.
Matthew, A. (2016), Hyperamylasemia: Medicare, .View Article
Mooren, Fch, Hlouschek, V., Finkes, T., Tuis, S., Weber, I.A., Singh, J. (2003) Early changes in pancreatic cell calcium signaling after pancreatic duct obstruction. J. Biolchem, 278 9361 -9.View Article
Ogra, R. Lane, M, Wong, P., & Fraser, a. (2002) Endoscopic injection therapy for non varieal upper gastrointestinal bleeding at Auck Land Hospital, Journal of New Zealand Medical Association, (115) 116, 1 ? 6.
Olubuyide, I.O. (1989). An autopsy survey of peptic ulcer disease at Ibadan. African Journal of medicine, 35 (10) 1-6.
Zajac, P., Holbrook, Super, M.E., Vogt, M. (2013). An OVerview: current clinical guidelines for the evaluation, diagnosis, treatment and management of dyspepsia. Osteopathic family physician (2): 79 ? 85.